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Treatment-resistant depression: Time to consider folate supplementation

March 18, 2013
  • Advising on this article:
  • M. Lynn Crismon

KEY POINT

In patients with major depressive disorder who had incomplete or no response to selective serotonin reuptake inhibitor (SSRI) therapy, addition of L-methylfolate 15 mg daily led to improved response rate and increased degree of change in depression symptom scores as compared with placebo.

SOURCES

Papakostas GI et al. L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized double-blind, parallel-sequential trials. Am J Psychiatry. 2012;169:1267–74.

Nelson JC. The evolving story of folate in depression and the therapeutic potential of L-methylfolate [editorial]. Am J Psychiatry. 2012;169:1223–5.

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