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Two novel treatments show promise in preventive treatment of migraines

January 9, 2018
  • Advising on this article:
  • Jack J. Chen

KEY POINT

Two investigational monoclonal antibodies that target either the calcitonin gene-related peptide (CGRP) receptor (i.e., erenumab) or CGRP itself (i.e., fremanezumab) were shown to be effective for preventive treatment of migraines compared with placebo, according to results from two Phase III studies published in the New England Journal of Medicine.

SOURCES

Goadsby PJ, et al. A controlled trial of erenumab for episodic migraine. N Engl J Med. 2017;377(22):2123–32.

Silberstein SD, et al. Fremanezumab for the preventive treatment of chronic migraine. N Engl J Med. 2017;377(22):2113–21.

Hershey AD. CGRP—the next frontier for migraine. N Engl J Med. 2017;377(22):2190–1.

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