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Ketogenic diet affects valproic acid, phenobarbital serum concentrations

January 28, 2019
  • Advising on this article:
  • Daniel S. Streetman

KEY POINT

Serum concentrations of valproic acid and phenobarbital appear to be significantly affected in patients receiving a ketogenic diet, whereas concentrations of other antiepileptic drugs (AEDs) seem to remain stable, according to results of an observational study published in the Journal of Clinical Pharmacy and Therapeutics.

SOURCES

Heo G, et al. Effect of ketogenic diet and other dietary therapies on anti-epileptic drug concentrations in patients with epilepsy. J Clin Pharm Ther. 2017;42(6):758–64. 

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