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PPIs decrease the effectiveness of hepatitis C antivirals

KEY POINT

Sustained virologic responses (SVRs) were lower in patients with hepatitis C taking direct-acting antivirals with proton pump inhibitors (PPIs) compared with those not receiving PPIs, according to results of a comprehensive review published in the Journal of Clinical and Translational Hepatology.

 

SOURCES

Wijarnpreecha K, et al. Efficacy and safety of direct-acting antivirals in hepatitis C virus–-infected patients taking proton pump inhibitors. J Clin Transl Hepatol. 2017;5(4):327–34.

Harvoni [package insert]. Foster City, CA: Gilead; 2017. Accessed February 18, 2018.

Epclusa [package insert]. Foster City, CA: Gilead; 2017. Accessed February 18, 2018.