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Testosterone replacement resulting in more harm than benefits

May 1, 2017
  • Advising on this article:
  • Frank Pucino

KEY POINT

Results from two testosterone replacement trials in older men with low testosterone levels showed that treatment with testosterone gel for 1 year was associated with a greater increase in coronary artery noncalcified plaque volume compared with placebo and was not associated with improvements in memory or cognitive functions.

SOURCES

Budoff MJ, et al. Testosterone treatment and coronary artery plaque volume in older men with low testosterone. JAMA. 2017;317(7):708–16.

Handelsman DJ, et al. Testosterone and male aging: Faltering hope for rejuvenation. JAMA. 2017;317(7):699–701.

Resnick SM, et al. Testosterone treatment and cognitive function in older men with low testosterone and age-associated memory impairment. JAMA. 2017;317(7):717–27. 

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